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In addition, under conditions of reduced oxygen tension guanosine can be modified to 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapydG), which together with 8-OHdG are the most abundantly formed oxidized forms of DNA bases

However, despite some success with agents like colchicine, the general class of broad anti-inflammatories often lacks specificity for the precise inflammatory pathways driving MIRI, leading to a poor risk-benefit profile and inconsistent efficacy in clinical trials for this acute setting

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While both NMN and NR are effective in raising NAD+ levels, they differ in their biochemical pathways and potential benefits